Sally Letter Adebamowo, Donna Spiegelman, Walter C Willett, Kathryn Yards Rexrode, Connection anywhere between intakes of magnesium, potassium, and you can calcium and likelihood of heart attack: dos cohorts of us lady and you can upgraded meta-analyses, New American Journal of Clinical Nutrition, Regularity 101, Thing 6, , Pages 1269–1277,
Conceptual
Background: Prospective investigation to your relatives of magnesium, potassium, and you will calcium supplements intakes having heart attack risk try contradictory, and to our very own studies, the outcome from a blended nutrient diet rating wasn’t checked.
Objective: I checked-out associations anywhere between consumption out of magnesium, potassium, and you will calcium supplements and threat of event coronary arrest during the 86,149 feamales in this new Nurses’ Fitness Investigation (NHS) We and you can 94,715 ladies in the fresh new NHS II.
Design: In this possible cohort study, we calculated Days out of coronary attack by the quintiles regarding intake per nutrient and also for a blended eating plan rating of all of the 3 minerals that with multivariate Cox proportional possibilities patterns. On the other hand, i current meta-analyses for the weight-loss consumption of these minerals and you will likelihood of coronary arrest.
Results: During the follow-up (31 y regarding NHS I; twenty two y in the NHS II) a maximum of 3780 experience stroke times have been noted. Pooled multivariate RRs from total coronary attack for women regarding the highest compared with a minimal quintiles was 0.87 (95% CI: 0.78, 0.97) getting overall magnesium, 0.89 (95% CI: 0.80, 0.99) having full potassium, and you may 0.97 (95% CI: 0.87, 1.09) having total calcium supplements consumption. Pooled RRs for women about high in contrast to a decreased quintiles out-of a blended nutrient diet score were 0.72 (95% CI: 0.65, 0.81) for complete heart attack, 0.78 (95% CI: 0.66, 0.92) to possess ischemic stroke, and you will 0.80 (95% CI: 0.61, step one.04) to own hemorrhagic coronary arrest. On the current meta-analyses of all potential training thus far, the mutual RR off overall coronary arrest are 0.87 (95% CI: 0.83, 0.92) to own a 100-mg/d rise in magnesium consumption, 0.91 (95% CI: 0.88, 0.94) to have an effective 1000-mg/d increase in potassium intake, and you will 0.98 (95% CI: 0.94, 1.02) for a three hundred-mg/d boost in calcium supplements consumption.
Conclusions: A mixed mineral diet plan score try inversely with the threat of stroke. Higher consumption out of magnesium and you may potassium but not calcium was indeed also rather regarding the faster risk of coronary attack in women.
Inclusion
Magnesium is a vital nutrient and you will cofactor getting >3 hundred enzymatic responses within the body ( 1). Magnesium ‘s the next extremely-abundant intracellular cation close to potassium ( 2). Calcium is considered the most-numerous mineral in the human body. Such as magnesium and potassium, calcium supplements is actually vitally doing work in cardiovascular characteristics ( 3). Higher slimming down consumption of each of those vitamins was indeed advertised so you can all the way down threat of blood pressure ( 4– 7), the principal modifiable coronary arrest exposure foundation. not, not all prospective knowledge checked out the latest family members anywhere between weight reduction and extra consumption of those nutrition and you will danger of stroke in women, and you may results was indeed inconsistent. Potential studies inside Europe shown magnesium intake, however intake away from potassium otherwise calcium supplements, is actually rather of the faster chance of coronary attack ( 7, 8). In the united states, consumption away from potassium and you can magnesium, not out of calcium supplements, were with the faster stroke chance inside the males ( 9), whereas calcium supplements and potassium consumption, but not magnesium intake, were of reduced coronary arrest chance in females ( 10). In addition to, one to studies shown zero full organization anywhere between these nutrients and you may risk of coronary arrest ( 11).
The few potential observational education that were conducted don’t include follow-upwards beyond fifteen y together with a relatively small number of event coronary attack incidents, and also in really degree, this new independent effectation of for every mineral consumption from drugs http://datingranking.net/std-dating-sites/ and you can coronary arrest sizes wasn’t checked. In this article, you can expect research toward association of each and every mineral consumption of diet and pills with danger of total, ischemic, and you will hemorrhagic incident shots. Simultaneously, we hypothesized one a combined diet plan get of all step 3 minerals is with the smaller coronary arrest exposure since these minerals can be found together with her inside the edibles, and intakes try strongly correlated. I managed these types of aims within the United states women that was basically implemented prospectively throughout the dos large cohorts the fresh Nurses’ Wellness Data (NHS) 5 I and II.
