RRs (95% CI) of full, ischemic, and you can hemorrhagic shots of the quintiles from mutual diet plan results to own magnesium, potassium, and you may calcium supplements intakes from inside the 86,149 women in the NHS I and you can 94,715 women in brand new NHS II 1
I upgraded new meta-analyses off prospective degree of weight-loss magnesium ( 21), potassium ( 22), and you may calcium ( 23) consumption and danger of coronary arrest
The multivariate model was adjusted for age, things to know when dating a Little People calendar year, total calories (quintiles of kcal), BMI (in kg/m 2 ; <25, 25 to <30, or ?30), parental history of heart disease (aged ?60 y), alcohol intake (0, 0 to <5, 5 to <10, 10 to <15, or ?15 g/d), physical activity (<3, 3 to <9, 9 to <18, 18 to <27, or ?27 metabolic equivalent tasks/wk), smoking, postmenopausal hormone therapy, oral contraceptive use (never, past, or current), menopausal status (premenopausal or postmenopausal), aspirin (0 to <2 or ?2 pills/wk), multivitamin, history of hypertension, hypercholesterolemia, diabetes at baseline, and thiazide use (yes or no). NHS, Nurses' Health Study.
RRs (95% CI) away from total, ischemic, and you will hemorrhagic strokes by quintiles off mutual diet ratings to possess magnesium, potassium, and you will calcium intakes for the 86,149 women in the latest NHS I and you can 94,715 women in the fresh NHS II step 1
We up-to-date the meta-analyses out of possible knowledge out-of fat loss magnesium ( 21), potassium ( 22), and you can calcium ( 23) intakes and you can likelihood of coronary attack
The multivariate model was adjusted for age, calendar year, total calories (quintiles of kcal), BMI (in kg/m 2 ; <25, 25 to <30, or ?30), parental history of heart disease (aged ?60 y), alcohol intake (0, 0 to <5, 5 to <10, 10 to <15, or ?15 g/d), physical activity (<3, 3 to <9, 9 to <18, 18 to <27, or ?27 metabolic equivalent tasks/wk), smoking, postmenopausal hormone therapy, oral contraceptive use (never, past, or current), menopausal status (premenopausal or postmenopausal), aspirin (0 to <2 or ?2 pills/wk), multivitamin, history of hypertension, hypercholesterolemia, diabetes at baseline, and thiazide use (yes or no). NHS, Nurses' Health Study.
We examined separately the relation between intakes of magnesium, potassium, and calcium from supplements and risk of stroke. There was no significant association between supplemental magnesium or calcium intake and risk of total, ischemic, or hemorrhagic stroke in the pooled analyses. We observed a significant inverse association between supplemental potassium intake and risk of ischemic but not total or hemorrhagic stroke. The pooled multivariate RR for comparison of highest with lowest quintiles of supplemental potassium intake was 0.71 (95% CI: 0.56, 0.89, P-trend < 0.01) for ischemic stroke. Pooled multivariate RRs for supplemental magnesium (Supplemental Table 7), supplemental potassium (Supplemental Table 8), and supplemental calcium (Supplemental Table 9) and risk of total, ischemic, and hemorrhagic strokes are shown in the supplemental material.
We checked-out total and you will fat loss consumption of each mineral and you will risk of coronary arrest to choose any possible nonlinear association that with restricted cubic splines; not, zero tall deviation off linearity try noticed. As well, i browsed the possibility effect amendment from the many years, blood pressure, otherwise diabetes with the relatives between complete intake of all step three nutritional elements and you may threat of full coronary attack. Zero high perception modification is noticed because of the this type of issues.
Prior meta-analyses integrated results from earlier analyses about NHS ( 10); these types of abilities had been changed because of the results in the modern research. In addition, the brand new literary works is searched, and you can previous prospective studies ( 8, 24) was basically found in these types of up-to-date meta-analyses. Zero between-degree heterogeneity is actually noticed when it comes to of step 3 nutrients. The newest shared RR regarding full heart attack try 0.87 (95% CI: 0.83, 0.92) getting a hundred-mg/d increase out-of magnesium consumption, 0.91 (95% CI: 0.88, 0.94) to possess good a lot of-mg/d raise out of potassium consumption, and you can 0.98 (95% CI: 0.94, step one.02) to possess a 300-mg/d boost of calcium intake.
